郭娜
发布人:食品科学与工程学院  发布时间:2016-06-22   浏览次数:167


    郭娜, 女,1980年3月生,博士。吉林省微量元素学会理事。吉林大学军需科技学院食品质量与安全系副教授,硕士生导师。2013年度教育部“新世纪优秀人才支持计划”和“吉林大学优秀青年基金后备人才培育计划暨吉林省高校优秀青年科研人才春苗培育计划”获得者。先后主持国家自然科学基金青年项目和面上项目各一项。研究成果获2012、2013年吉林省自然科学学术成果一等奖,2013年吉林省科学技术奖二等奖。申请者近年来致力于天然抗菌化合物的筛选及分子作用机制研究,  始终坚持在国内教学科研第一线。发表SCI检索论文27篇。授权专利4项。参与出版著作3部。

学术任职:

吉林省微量元素学会会员。

学习工作经历

1999~2003  年在山西农业大学动物医学系本科学习,获学士学位。

2003~2006  年在山西农业大学基础兽医系读研究生,获硕士学位。

2006~2009  年在吉林大学基础兽医系读博士研究生,获博士学位。

2009~至今 在吉林大学军需科技学院工作,讲师、  副教授,硕士生导师。

科研项目:

[1]国家自然基金青年项目-《天然防腐剂尼生素抗菌作用的分子机制研究》(31000822)  

[2]国家自然科学基金面上项目-《茶树油对SarA介导的金黄色葡萄球菌生物被膜形成的干预机制研究》  

 [3] 2013年度教育部“新世纪优秀人才”  -《基于干扰食源性细菌自溶程序的抗生物膜天然化合物筛选与新药靶研究》

[4]2013年度吉林大学优秀青年基金后备人才培育计划暨吉林省高校优秀青年科研人才春苗培育计划-《基于QS调控系统研究辅酶Q对食源性金黄色葡萄球菌生物被膜形成的干预机制》  

[5]国家十一五科技支撑计划-《抗耐药菌中兽药的研制与研发》  

[6]吉林省地方标准-《饮料中微量4-甲基咪唑的高效色谱检测方法》、《豆芽中连二亚硫酸钠的检测-高效离子色谱法》  

[7]吉林大学农学部人才引进建设专项课题-《食品防腐保鲜剂茴香醛的抗真菌转录组学研究》  

发表论文

[1] Guo N, Yu L, Meng R, Fan J,  Wang D, Sun G, Deng X. Global gene expression profile of Saccharomyces  cerevisiae induced by dictamnine. Yeast. 2008, 25(9):631-641. (影响因子: 1.895) [2] Yu L, Xiang H, Fan J, Wang  D, Yang F, Guo N, Jin Q, Deng X. Global transcriptional response of  Staphylococcus aureus to rhein, a natural plant product. J Biotechnol. 2008,  135(3):304-308. (影响因子: 3.045)

[3] Wang D, Yu L, Xiang H, Fan  J, He L, Guo N, Feng H, Deng X. Global transcriptional profiling of  Staphylococcus aureus treated with berberine chloride. FEMS Microbiol Lett.  2008, 279(2):217-225. (影响因子: 2.044)

[4] Feng H, Xiang H, Zhang J,  Liu G, Guo N, Wang X, Wu X, Deng X, Yu L. Genome-wide transcriptional profiling  of the response of Staphylococcus aureus to Cryptotanshinone. J Biomed  Biotechnol. 2009, 617509. (影响因子: 2.436)

[5] Guo N, Liu J, Wu X, Bi X,  Meng R, Wang X, Xiang H, Deng X, Yu L. Antifungal activity of thymol against  clinical isolates of fluconazole-sensitive and -resistant Candida albicans. J  Med Microbiol. 2009, 58(Pt 8):1074-1079. (影响因子: 2.502)

[6] Yu L, Guo N, Yang Y, Wu X,  Meng R, Fan J, Ge F, Wang X, Liu J, Deng X. Microarray analysis of  p-anisaldehyde-induced transcriptome of Saccharomyces cerevisiae. J Ind  Microbiol Biotechnol. 2010, 37(3):313-322. (影响因子: 2.735)

[7] Guo N, Wu X, Yu L, Liu J,  Meng R, Jin J, Lu H, Wang X, Yan S, Deng X. In Vitro and In Vivo Interractions  between Fluconazole and Allicin against Clinical Isolates of  Fluconazole-Resistant Candida albicans Determined by Alternative Methods. FEMS  Immunol Med Microbiol. 2010, 58(2):193-201. (影响因子: 2.441).

[8] Guo N, Ling G, Liang X, Jin  J, Fan J, Qiu J, Song Y, Huang N, Wu X, Wang X, Deng X, Deng X, Yu L. In Vitro  synergy of pseudolaric acid B and fluconazole against clinical isolates of  Candida albicans. Mycoses. 2010, 54(5):e400-406. (影响因子: 2.247)

[9] Yu L, Guo N*(通讯作者), Meng R,  Liu B, Tang X, Jin J, Cui Y, Deng X. Allicin-induced global gene expression  profile of Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2010,  88(1):219-229. (影响因子: 3.425)

[10] Bi X, Guo N, Jin J, Liu J,  Feng H, Shi J, Xiang H, Wu X, Dong J, Hu H, Yan S, Yu C, Wang X, Deng X, Yu L.  The global gene expression profile of the model fungus Saccharomyces cerevisiae  induced by thymol. J Appl Microbiol. 2010, 108(2):712-722. (影响因子: 2.337)  

[11] Jin J, Guo N, Zhang J,  Ding Y, Tang X, Liang J, Li L, Deng X, Yu L. The Synergy of Honokiol and  Fluconazole against Clinical Isolates of Azole-Resistant Candida albicans. Lett  Appl Microbiol. 2010, 51(3):351-357. (影响因子: 1.622)

[12] Ge F, Zeng F, Guo N, Fan  J, Song Y, Liu S, Wu X, Wang X, Deng X, Jin Q, Yu L. In vitro synergistic  activity between 8-methoxypsoralen and ethambutol, isoniazid, and rifampin when  used in combination against Mycobacterium tuberculosis. World J Microb Biot.  2010, 26(4):623-628. (影响因子: 1.532).

[13] Ge F, Zeng F, Liu S, Guo  N, Ye H, Song Y, Fan J, Wu X, Wang X, Deng X, Jin Q, Yu L. In vitro synergistic  interactions of oleanolic acid in combination with isoniazid, rifampicin or  ethambutol against Mycobacterium tuberculosis. J Med Microbiol. 2010, 59(Pt  5):567-572. (影响因子: 2.502)

[14] Jin J, Zhang JY, Guo N,  Sheng H, Li L, Liang JC, Wang XL, Li Y, Liu MY, Wu XP, Yu L. Farnesol, a  Potential Efflux Pump Inhibitor in Mycobacterium smegmatis. Molecules. 2010,  15(11):7750-7762. (影响因子: 2.386)

[15] Jin J, Zhang J, Guo N,  Feng H, Li L, Liang J, Sun K, Wu X, Wang X, Liu M, Deng X, Yu L. The plant  alkaloid piperine as a potential inhibitor of bromide efflux in ethidium  Mycobacterium smegmatis. J Med Microbiol. 2011, 11, 60(Pt 2):223-229. (影响因子:  2.502)

[16] Li L, Li Z, Guo N, Jin J,  Du R, Liang J, Wu X, Wang X, Liu M, Jin Q, Yu L. Synergistic activity of  1-(1-Naphthylmethyl)-piperazine with ciprofloxacin against clinically resistant  Staphylococcus aureus, as determined by different methods. Lett Appl Microbiol.  2011, 52(4):372-378. (影响因子: 1.622)

[17] Haiqing Ye, Zengshan Liu,  Aizhen Guo, Junchao Liang, Na Guo, Fanli Zeng, Liqiang Liu, Lei Li, Jing Jin,  Xiuping Wu, Yang Li, Mingyuan Liu, Qi Jin, Lu Yu. Global transcriptional  profiles ofMycobacterium tuberculosis treated with plumbagin. World J Microbiol  Biotechnol. 2011, 27(10): 2261-2269. (影响因子:1.532)

[18] Liu G, Liang J, Wang X, Li  Z, Wang W, Guo N, Wu X, Shen F, Xing M, Liu L, Li L, Liu M, Yu L. In Vitro  Synergy of Biochanin A and Ciprofloxacin against Clinical Isolates of  Staphylococcus aureus. Molecules 2011, 16(8), 6656-6666. (影响因子: 2.386)  

[19] Liu G, Xiang H, Tang X,  Zhang K, Wu X, Wang X, Guo N, Feng H, Wang G, Liu L, Shi Q, Shen F, Xing M, Yuan  P, Liu M, Yu L. Transcriptional and functional analysis shows sodium  houttuyfonate-mediated inhibition of autolysis in Staphylococcus aureus.  Molecules. Molecules 2011, 16(10), 8848-8865. (影响因子: 2.386)

[20] Yu L, Ling G, Deng X, Jin  J, Jin Q, Guo N*(通讯作者). In Vitro Interaction between Fluconazole and Triclosan  against Clinical Isolates of Fluconazole-Resistant Candida albicans Determined  by Different Methods. Antimicrob Agents Chemother. 2011, 55(7):3609-3612. (影响因子:  4.841)

[21] Liang J, Zeng F, Guo A,  Liu L, Guo N, Li L, Jin J, Wu X, Liu M, Zhao D, Li Y, Jin Q, Yu L. Microarray  analysis of the chelerythrine-induced transcriptome of Mycobacterium  tuberculosis. Curr Microbiol. 2011, 62(4):1200-1208.  (影响因子: 1.815).

[22] Wang D, Jin Q, Xiang H,  Wang W, Guo N, Zhang K, Tang X, Meng R, Feng H, Liu L, Wang X, Liang J, Shen F,  Xing M, Deng X, Yu L. Transcriptional and functional analysis of the effect of  magnolol: inhibition of autolysis and biofilms in Staphylococcus aureus. PLoS  One. 2011, 6(10):e26833. (影响因子: 4.092)

[23] Liang J, Tang X, Guo N,  Zhang K, Guo A, Wu X, Wang X, Guan Z, Liu L, Shen F, Xing M, Liu L, Li L, Yu L.  Genome-wide expression profiling of the response to Linezolid in Mycobacterium  tuberculosis. Curr Microbiol. 2012, 64:530–538. (影响因子: 1.815)

[24] Li L, Shen W, Zhang K,  Tang X, Guo N, Shen F, Xing M, Liu L, Yuan P, Shi Q, Liang J, Yu L. In vitro  antimycoplasmal activity of triclosan in combination with fluoroquinolones  against five mycoplasma species. Iranian Journal of Pharmaceutical Research.  2012, 11(4):1111-1119. (影响因子: 0.637)

[25] Xing MX, Shen FG, Liu LH,  Chen ZB, Guo N, Wang XL, Wang W, Zhang KY, Wu XP, Wang X, Li Y, Sun SM, Yu L.  Antimicrobial efficacy of the alkaloid harmaline alone and in combination with  chlorhexidine digluconate against clinical isolates of Staphylococcus aureus  grown in planktonic and biofilm cultures. Letters in Applied Microbiology. 2012,  54:475–482. (影响因子: 1.622)

[26] Jian Wei, Na Guo, Junchao  Liang, Peng Yuan, Qiyun Shi, Xudong Tang, Lu Yu. DNA Microarray Gene Expression  Profile of the Mycobacterium tuberculosis when exposed to osthole. Pol J  Microbiology. 2013.62(1): 23–30. (影响因子: 0.76)

[27] N. Guo, J. Wu, J. Fan, P.  Yuan, Q. Shi, K. Jin, W. Cheng, X. Zhao, Y. Zhang, W. Li, X. Tang and L. Yu. In  vitro activity of isoimperatorin, alone and in combination, against  Mycobacterium tuberculosis. Letters in Applied Microbiology. 2013 Dec 12. doi:  10.1111/lam.12195.(影响因子:1.629)

专利

[1]三氯生作为抗真菌药物氟康唑增效剂的新用途。授权国家:中国。排名:第三。  

[2]  一种提高氟康唑抗真菌作用的增效剂。授权国家:中国。排名:第三。

[3]  一种具有与氟康唑协同抗真菌作用的增效剂。授权国家:中国。排名:第五。

[4]一种提高乙胺丁醇抗分支杆菌作用的增效剂。授权国家:中国。排名:第四。  

获奖情况

[1] 2012吉林省自然科学学术成果奖一等奖。排名:第二。  

[2] 2013吉林省自然科学学术成果奖一等奖。排名:第一。  

[3] 2013年吉林省自然科学将二等奖。排名:第三。  

编著情况

[1]药物毒理学. 副主编. 2009,  黑龙江科学技术出版社.

[2] Veterinary Pharmacology and  Therapeutics Ninth edition, 编者. 2012, 中国农业出版社.

联系方式

联系电话:0431-87836376;  电子信箱:abas1980@163.com