关爽
发布人:食品科学与工程学院  发布时间:2016-06-21   浏览次数:


  关爽,副教授,博士生导师。毕业于吉林大学,获得药理学博士学位,康奈尔大学访问学者。主讲《食品毒理学》、《食品免疫学》、《食品质量与安全》和《分子毒理学》(研究生课)。近年来主持或参加多项省部级科研课题及企业课题,以第一作者或通讯作者发表SCI论文约28篇。主要从事食品中有害物质毒性机理及安全评价研究、长白山特色资源综合开发研究。

学术任职:

中国毒理学会会员、吉林省食品学会会员。

受教育经历

1992-1996 长春中医学院 中药系 学士

2007-2009 吉林大学 军需科技学院食品科学系 硕士

2009-2011 吉林大学 畜牧兽医学院基础兽医系 博士

研究工作经历

2000-2009 吉林亚泰药业 新药研发部 研究员

2012-2015 吉林大学军需科技学院食品质量与安全系 讲师

2015-现在 吉林大学食品科学与工程学院 副教授

2013/03-2013/11 美国康奈尔大学 农业与生命学院 食品系 访问学者

2012-2016 吉林大学 畜牧兽医学院(动物科学学院)生物化学与分子生物学 博士后

科研项目

1、主持国家自然科学国际合作项目子课题,抗沙门氏菌三型分泌系统天然化合物的筛选,2017-2021 149.75万元;

2、主持十二五科技支撑项目子课题,林蛙骨补钙制剂的研究及相关产品开发,2013-201780万元;

3、主持国家教育部博士点基金项目(新教师类),3--12-丙二醇抑制小鼠T淋巴细胞的毒性,2014-20174万元;

4、主持博士后科学基金面上项目,苯并芘对小鼠T淋巴细胞的抑制作用,2013-201610万元;

5、主持企业项目,林蛙多肽口服液技术开发(委托)项目,2013-201710万;

6、参加吉林省科技厅重点项目,林蛙综合深加工技术研究开发,2018-202080万;

7、参加吉林省世行贷款项目,吉林省养殖鱼类常见细菌性病害新药筛选,2012-201425万元;

8、参加吉林省科技厅重点项目,玉米汁中农药残留快速检测及控制技术的研究,2012-201414万元;

近几年发表论文

[1] Cheng, BJ; Lu, J ; Li, TJ ; Meng, ZQ ; Liu, MT; Guan Shuang(*). 1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. FOOD AND CHEMICAL TOXICOLOGY. 2018(122):143-150

[1] Lu J, Cheng B, Meng Z, Fang B, Li T, Sun M, Liu M, Guan Shuang(*). Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.Life Sci. 2018 Feb 15;195:19-24.

[2] Lu J, Cheng B, Fang B, Meng Z, Zheng Y, Tian X, Guan Shuang(*). Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells.Biomed Pharmacother. 2017 Dec;96:1411-1417.

[3] Lu J, Fang B, Zheng Y, Yu X, Huang G, Wang Z, Deng X, Guan Shuang(*).1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors.Environ Toxicol Pharmacol. 2017 Oct;55:118-126.

[4] Guan, Shuang ; Zheng, Yiying; Yu, Xin; Lu, Jing. Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10. FOOD AND AGRICULTURAL IMMUNOLOGY,2017:28(6):1347-1361

[5] Guan, Shuang ; Yu, Xin; Fang, Baochen; Lu, JingThe toxicity of 3-monochloro-1,2-propanediol (+) to activated T cells in mice. AGRICULTURAL IMMUNOLOGY:28(4):612-624.

[6] Guan S, Huang Y, Feng Z, Xu L, Jin Y, Lu J. The toxic effects of benzo[a]pyrene on activated mouse T cells in vitro. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):117-123.

[7] Lu J, Wang Z, Ren M, Huang G, Fang B, Bu X, Liu Y, Guan Shuang(*).Antibacterial Effect of Gallic Acid against Aeromonas hydrophila and Aeromonas sobria Through Damaging Membrane Integrity.Curr Pharm Biotechnol. 2016;17(13):1153-1158.

[8] Jin Y, Wang Y, Zhao D, Ma S, Lu J, Guan Shuang(*).Pristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.Immunopharmacol Immunotoxicol. 2016 Jun;38(3):221-7

[9] jing lu (#)Ren Mengrou(#)Fang BaochenHuang GuorenZhang ShuangWang YiDeng Xuming(*)Guan Shuang(*)Nonalcoholic fatty liver disease induced by 13-week oral administration of 1,3-dichloro-2-propanol in C57BL/6J miceEnviron Toxicol Pharmacol2015393):1115-1121

[10] jing lu (#) Wang ZhenningRen MengrouFeng GuangxinYe BeiningWang YiFang BaochenDeng XumingGuan Shuang(*)A 4-week study of four 3-monochloropropane-1,2-diol diesters on lipid metabolism in C57BL/6J miceEnviron Toxicol Pharmacol2015.9.01402):453-458

[11] Lu JingHuang, GuorenHu, SizhuoWang, ZhenningGuan, Shuang(*)1,3-Dichloro-2-propanol induced hyperlipidemia in C57BL/6J mice via AMPK signaling pathwayFood and Chemical Toxicology201464403~409

[12] Jing Lu (#)Guoren Huang(#) Bocui SongZhenning WangLinli XuShuonan ZhangShuang Guan(*)The inhibition of 2,3-dichloro-1-Propanol on T cell in vitro and in vivoInternational Immunopharmacology2013172):321~328

[13] Jing Lu (#) Guoren HuangZhenning WangShuang ZhuangLinli XuBocui SongYing XiongShuang Guan (*)Tyrosol exhibits negative regulatory effects on LPS response and endotoxemiaFood and Chemical Toxicology201362172~178

[14] Bocui Song (#)Shuang Guan(#)Jing Lu (#)Zhibao ChenGuoren HuangGen LiYing XiongShuang ZhangZhanpeng Yue(*)Xuming Deng(*)Suppressive effects of fisetin on mice T lymphocytes in vitro and in vivoJournal of Surgical Research2013.11.011851):399~409

[15] Ying Xiong(#)Shuang Zhang(#)Jing Lu (#) Shicheng SunBocui SongLinli XuZhenguo Yang(*)Shuang Guan(*)Investigation of effects of farrerol on suppression of murine T lymphocyte activation in vitro and in vivoInternational Immunopharmacology2013162):313~321

[16] Jing Lu (#)Wenhui Qian(#)Linli Xu Guoren HuangWen CongZhenning WangXuming DengDacheng WangShuang Guan(*)Phytochemical composition andtoxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) NakaiEnvironmental Toxicology and Pharmacology2012342):409~415

[17] Guan Shuang, Song Yu, Guo Weixiao, Chu Xiao, Zhang Xiaozhe, Wang Dacheng, Lu Jing, Deng Xuming. Immunosuppressive activity of tilmicosin on the immune responses in mice. Immunopharmacol Immunotoxicol, 33(2), 323-8, 2011.

[18] Shuang Guan, Yu Songa, Weixiao Guoa, Zhenguo Yang, Jing Lu,Xuming Deng. Immunosuppressive activity of Florfenicolon on the immune responses in mice. Immunological Investigations, 40(4), 356-66, 2011.

[19] Guan Shuang, Feng Haihua, Song Bocui, Guo Weixiao, Xiong Ying, Huang Guoren, Zhong Weiting, Huo Meixia, Chen Na,Lu, Jing, Deng Xuming. Salidroside attenuates LPS-induced pro-inflammatory cytokine responses and improves survival in murine endotoxemia. International immunopharmacology,11(12), 2194-2199, 2011.

[20] Shuang Guan, Lu Jing, Weixiao Guo, Xuming Deng. Adjuvant effects of salidroside from Rhodiola rosea L.on the immune responses to ovalbumin in mice. Immunopharmacology And Immunotoxicology, 33 (4), 738-743, 2011.

[21] Shuang Guan,Jing Lu, Wenhui Qian, Jingbo Liu, Xuming Deng. Florfenicol impairs the immune responses to vaccination against foot-and-mouth disease in mice. Immunopharmacology and immunotoxicology, 33 (4), 609-613, 2011.

[22] Guan S, Wang W, Lu J, Qian W, Huang G, Deng X, Wang X. Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway. Molecules,16(4), 3371-9, 2011.

[23] Shuang Guan, Ying Xiong, Bocui Song, Yu Song , Dacheng Wang, Xiao Chu, Na Chen, Meixia Huo, Xuming Deng , Jing Lu. Protective Effects of salidroside from Rhodiola rosea on LPS-Induced Acute Lung Injury in Mice. Immunopharmacology and immunotoxicology, 34(4), 667-672, 2012.

[24]Lanan Wassy Soromou, Rongtao Li , Weixiao Guo , Weiting Zhong, Na Chen, Meixia Huo, Jing Lu, Shuang Guan*, Xuming Deng, Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methylnaringenin. Molecules. 2011.

[25] Shuang Guan, Jing Lu, Xue Shen, Wenhui Qian, Guoren Huang, Dacheng Wang, Xuming Deng, Guanghong Xie. Immunosuppressive activity of 8-gingerol on the immune responses in mice.Molecules,16(3), 2636-45, 2011.

[26] Guan Shuang,Lu Jing , Liu Jingbo, Guo Na, Shen Xue, Qian Wenhui, Deng Xuming. In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice. Lat. Am. J.Pharm, 30 (1), 112-118, 2010.

[27] Jing Lu, Wenhui Qian, Linli Xua, Guoren Huang, Wen Cong, Zhenning Wang, Xuming Deng, Dacheng Wang, Shuang Guan*. Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai. Environmental toxicology andpharmacology, 34, 409-415, 2012.

 

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