Zhang Tiehua, born in October 1970, male, professor, doctor of engineering, doctoral supervisor. Dean of the School of Food Science and Engineering of Jilin University, director of the Engineering Technology Research Center for High-value Utilization of Animal By-products in Jilin Province, director of the Zuodanli Healthy Food Research and Development Center of Jilin University, and outstanding contribution expert of Jilin Province. The main research direction is food deep processing and biotechnology. He has presided over and undertook more than 20 various topics such as national key research and development plans, science and technology support plans, natural science foundations and Jilin Province Science and Technology Department. He has published more than 110 papers, including more than 80 papers included in SCI and EI. He has obtained 16 national invention patents, 5 transferred patents, 8 awards, and compiled more than 20 teaching materials. Part-time as an editorial board member of journals such as Food Science, Food and Biotechnology Journal, Food Industry Technology, Food Research and Development, and eFood.
Email: E-mail:zhangth@jlu.edu.cn
1. Educational experience:
2004/09-2008/06 PhD, College of Biological and Agricultural Engineering, Jilin University
1991/09-1995/07 Northeast Agricultural University, Department of Food Science and Engineering, Bachelor
2. Work experience:
2015/07-present, Professor, School of Food Science and Engineering, Jilin University
2011/05-2012/06 University of Vermont (University of Vermont) Nutrition and Food Science Visiting Scholar
2008/12-2011/04 China Agricultural Science and Technology Northeast Innovation Center, Food Science, Postdoctoral Research
2004/09-2015/06 Lecturer/Associate Professor/Professor, Quartermaster Technology College, Jilin University
1999/09-2004/08, Assistant Professor/Lecturer, Department of Quartermaster Engineering, Quartermaster University, People's Liberation Army
1995/07-1999/08 Assistant Professor, Department of Veterinary Medicine, PLA University of Agriculture and Animal Husbandry
3. Social part-time job:
Deputy Chairman of the Blockchain Professional Committee of China Food and Drug Enterprise Quality and Safety Promotion Association
Member of the Professional Committee of Space Microbiology and Infection, Chinese Research Hospital Association
Deputy Chairman of the Health Food Subcommittee of Jilin Pharmaceutical Association
Executive Director of Jilin Food Association
4. Representative scientific research projects:
(1) The task of the 13th Five-Year National Key Research and Development Plan, the directed separation and preparation of special functional protein components in fresh milk, project number 2017YFD0400603, 2017.7-2020.12, presided over.
(2) A general project of the National Natural Science Foundation of China, Fluorescence polarization detection of bisphenol-diglycidyl ether and endocrine disrupting effects in canned food based on estrogen receptors, project number 31871717, 2019.01-2022.12, presided over.
(3) The special project of Jilin Province School Co-construction Plan, research and industrialization of key technologies for high-value processing and safety control of agricultural products, project number SF2017-6-4, 2017.01-2020.12, presided over.
(4) The transformation project of the Department of Science and Technology of Jilin Province, the development of velvet antler polypeptide oral liquid, project number 20160441003SC, 2016.01-2018.12, presided over.
(5) The National Science and Technology Support Program, the development of whey protein-based fat substitutes, project number 2013BAD18B07-0101 2013.01-2016.12, presided over.
(6) Key scientific and technological research project of Jilin Provincial Department of Science and Technology, research on key technology of probiotic compound microecological additive preparation, project number 20130206048NY, 2013.01-2015.12, presided over.
(7) Achievement Transformation Project of Jilin Provincial Department of Science and Technology, development of functional peptides of Rana chensinensis oil and active milk health drinks, project number 20125066, 2012.01-2014.12, presided over.
5. Representative academic papers:
(1) Tiehua Zhang, Shuning Zhong, Tiezhu Li, Jie Zhang*. Saponins as modulators of nuclear receptors. Critical Reviews in Food Science and Nutrition, 2020, 60(1): 94-107. (1 Zone IF=6.704) No. One author, highly cited paper
(2) Tiehua Zhang, Yuan Liang, Jie Zhang*. Natural and synthetic compounds as dissociated agonists of glucocorticoid receptor. Pharmacological Research, 2020, 156: 104802. (1区IF=5.574) First author
(3) Tiehua Zhang, Yuan Liang, Peng Zuo, Siyuan Jing, Tiezhu Li, Yongjun Wang, Chengyu Lv, Da Li, Jie Zhang*, Zhengyi Wei*. 20(S)-Protopanaxadiol blocks cell cycle progression by targeting epidermal growth factor receptor. Food and Chemical Toxicology, 2020, 135: 111017. (1 Zone IF=3.775) First author
(4) Tiehua Zhang, Shuning Zhong, Ligang Hou, Yongjun Wang, XiaoJia Xing, Tianzhu Guan, Jie Zhang*, Tiezhu Li*. Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol. Journal of Ginseng Research, 2020, 44:690-696 (District 1 IF=4.029)) First author
(5) Chunyu Xi, Naixin Kang, Changhui Zhao, Yujia Liu, Zhengwei Sun, Tiehua Zhang*. Effects of pH and different sugars on the structures and emulsification properties of whey protein isolate-sugar conjugates. Food Bioscience, 2020, 33: 100507 . (2 Zone IF=3.22) Corresponding Author
(6) Tiehua Zhang, Yuan Liang, Peng Zuo, Mi Yan, Siyuan Jing, Tiezhu Li, Yongjun Wang, Jie Zhang*, Zhengyi Wei*. Identification of 20(R, S)-protopanaxadiol and 20(R, S)- protopanaxatriol for potential selective modulation of glucocorticoid receptor. Food and Chemical Toxicology, 2019, 131: 110642. (1区IF=3.775) First author
(7) Jie Zhang, Yifan Song, Yuan Liang, Haoyang Zou, Peng Zuo, Mi Yan, Siyuan Jing, Tiezhu Li, Yongjun Wang, Da Li, Tiehua Zhang*, Zhengyi Wei*. Cucurbitacin IIa interferes with EGFR-MAPK signaling pathway leads to proliferation inhibition in A549 cells. Food and Chemical Toxicology, 2019, 132: 110654. (1 District IF=3.775) Corresponding author
(8) Tiehua Zhang, Shuning Zhong, Yongjun Wang, Shuyue Dong, Tianzhu Guan, Ligang Hou, XiaoJia Xing, Jie Zhang*, Tiezhu Li*. In vitro and in silico perspectives on estrogenicity of tanshinones from Salvia miltiorrhiza. Food Chemistry, 2019 , 270: 281-286. (1 Zone IF=4.946)
(9) Pingping Hou, Fengling Pu, Haoyang Zou, Mengxue Diao, Changhui Zhao, Chunyu Xi*, Tiehua Zhang*. Whey protein stabilized nanoemulsion: A potential delivery system for ginsenoside Rg3 whey protein stabilized nanoemulsion: Potential Rg3 delivery system. Food Bioscience , 2019, 31: 100427. (District 2 IF=3.22) Corresponding author
(10) Ruifang Su, Hongru Zheng, Shuyue Dong, Rui Sun, Shangna Qiao, Hongjing Sun, Xinyue Ma, Tiehua Zhang*, Chunyan Sun*. Facile detection of melamine by a FAM–aptamer–G-quadruplex construct. Analytical and Bioanalytical Chemistry, 2019, 411(12): 2521-2530. (District 2 IF=3.286) Corresponding author
(11) Jie Zhang, Tiezhu Li, Tuoyi Wang, Cuiping Yuan, Shuning Zhong, Tianzhu Guan, Zhuolin Li, Yongzhi Wang, Hansong Yu, Quan Luo, Yongjun Wang*, Tiehua Zhang*. Estrogenicity of halogenated bisphenol A: in vitro and in silico investigations. Archives of Toxicology, 2018, 92(3): 1215-1223. (1 District IF=5.901)
(12) Jie Zhang, Wenfu Wu, Yongjun Wang, XiaoJia Xing, Shuning Zhong, Tianzhu Guan, Tiehua Zhang*, Ligang Hou*, Tiezhu Li*. Estrogen receptor-based fluorescence polarization assay for bisphenol analogues and molecular modeling study of their complexation mechanism. Analytica Chimica Acta, 2018, 1032: 107-113. (District 1 IF=5.123)
(13) Tiehua Zhang, Yang Yang, Yuan Liang, Xu Jiao, Changhui Zhao*. Beneficial effect of intestinal fermentation of natural polysaccharides. Nutrients, 2018, 10(8), 1055. (3 area IF=4.196)
(14) Chunyan Sun, Ruifang Su, Jiaxin Bie, Hongjing Sun, Shangna Qiao, Xinyue Ma, Rui Sun, Tiehua Zhang*. Label-free fluorescent sensor based on aptamer and thiazole orange for the detection of
tetracycline. Dyes and Pigments, 2018, 149: 867–875. (District 1 IF=3.473)
(15) Sun, Mao-cheng; Zhang, Fu-cheng; Yin, Xue; Cheng, Bi-jun; Zhao, Chang-hui; Wang, Yan-ling; Zhang, Zheng-zhe; Hao, Hong-wei; Zhang , Tie-hua*; Ye,Hai-qing*. Lactobacillus reuteri F-9-35 Prevents DSS-Induced Colitis by Inhibiting Proinflammatory Gene Expression and Restoring the Gut Microbiota in Mice. Journal of Food Science, 2018,83(10): 2645-2652, (3 zone IF=2.018)
(16) Xu Yanyang; Liu Hui; Huo Bingyang; Zhang Tiehua*; Zhang Yan. The effect of nitrogen-filled packaging on the quality of fresh ginseng and prediction of shelf life, Food Science, 2018,39(17):236-240(EI indexed)
(17) Zhao Chao; Ye Haiqing; Hou Pingping; Yang Yang; Zhou Xinhui. Zhang Tiehua*. The process optimization and fatty acid composition analysis of microwave-assisted extraction of forest frog egg oil, Food Science, 2017,38(22):263-268(EI indexed)
(18) Haiqing Ye, Qian Li, Zhengzhe Zhang, Maocheng Sun, Changhui Zhao, Tiehua Zhang*. Effect of a novel potential probiotic Lactobacillus paracasei Jlus66 isolated from fermented milk on nonalcoholic fatty liver in rats. Food & Function, 2017, 8( 12): 4539-4546. (District 1 IF=3.247) 200
(19) Tiehua Zhang, James McCarthy, Guorong Wang, Yanyan Liu, Mingruo Guo*. Physiochemical properties, microstructure, and probiotic survivability of nonfat goats' milk yogurt using heat-treated whey protein concentrate as fat replacer. Journal of Food Science, 2015 , 80(4): M788-M794. (3 zone IF=1.815)
6. Representative publications
(1) Health Food Science (Thirteenth Five-Year National Planning Textbook), China Light Industry Press, 2016, Associate Editor
(2) Modern Food Microbiology (Eleventh Five-Year National Planning Textbook), China Light Industry Press, 2011, co-edited
(3) Experimental textbook for food quality and safety, Jilin University Press, 2011, associate editor
(4) Experimental Textbook for Food Science and Engineering, Chemical Industry Press, 2010, Associate Editor
7. Representative awards
(1) Evaluation of endocrine disrupting effects and residue detection of typical persistent organic pollutants based on receptor recognition (Certificate No.: 2020Z20025), the second prize of Jilin Province Science and Technology Award
(2) Research on food safety detection technology based on nanoprobes and new molecular recognition (certificate number 2018Z20007), the second prize of Jilin Province Science and Technology Award
(3) Basic research on the structure and biological activity of food-derived bioactive peptides (Certificate No.: 2015Z20012), the second prize of Jilin Province Science and Technology Award
(4) The mechanism of action of cinnamaldehyde on Escherichia coli and Staphylococcus aureus (Certificate No. 20173094), the third prize of Jilin Province Natural Science Academic Achievement Award
(5) Preparation, structure characterization and activity screening of egg white-derived biologically active peptides (Certificate No.: 2011B-058), the second prize of Jilin Province Natural Science Academic Achievement
(6) Research on beef tenderization, serial products and quality standards (project number 970204-3), the second prize of Jilin Province Science and Technology Award
(7) Research and practice of the "three-in-one" education model of engineering education, innovation education and quality education in food science and engineering (certificate number: 20140215), the third prize of Jilin Provincial Department of Education
(8) Course Construction and Reform of "Functional Food Science" (Certificate Number: 200991041), First Prize of Jilin University
8. Representative authorized patents
(1) A new method for continuous separation and preparation of functional milk proteins in fresh milk, authorization number ZL 2019113713989, authorization time 2021.1.15
(2) A new preparation method of ginseng honey tablets, authorization number ZL201510164030.0, authorization date: 2018.3.1 (transferred)
(3) Ginseng polysaccharide viable whey beverage and its preparation method, authorization number ZL 201110404757.3 authorization date: 2014.4.9 (transferred)
(4) A fermented beverage with Rana sylvatica oil and its preparation method, authorization number ZL 201310010047.1 authorization date: 2014.01.29
(5) A Rana temporaria oil peptide granule and its preparation method, authorization number ZL 201310010049.0 authorization date: 2014.4.9
(6) A preparation method of fermented soybean whey juice beverage and high-protein live bacteria chewable tablets, authorization number ZL 201310006558.6 (transferred) 2014.8.6
(7) A probiotic microecological tablet and its preparation method, authorization number ZL 201410129017.7 Authorization date: 2016.06.01 (transferred)
(8) A composite probiotic microecological feed additive and its preparation method, authorization number ZL 201410139232.5 authorization date: 2016.01.25 (transferred)
(9) A method for preparing mineral-containing whey protein nanoparticles, authorization number ZL 201410255375.2, authorization date: 2015.12.30
