梁媛，1995年3月生，女，副教授，博士。研究方向为食品营养及毒理，主要包括：（1）食品污染物的内分泌干扰效应研究；（2）天然产物的生物活性与作用机制研究。近五年，以第一/通讯作者发表SCI论文十余篇。主持国家自然科学基金青年基金项目1项、中国博士后科学基金面上资助1项、吉林省科技厅项目2项、吉林大学博士研究生交叉学科科研资助计划1项。
联系方式：
邮箱：liangyuan@jlu.edu.cn 电话：15584472505
1.教育经历
2017.09-2021.12 吉林大学 食品科学与工程学院 （本）硕博连读 工学博士学位
2013.09-2017.07 吉林大学 食品科学与工程学院 本科 工学学士学位
2.工作经历
2024.09-至今 吉林大学 食品科学与工程学院 副教授
2024.02-2024.09 吉林大学 食品科学与工程学院 讲师
2021.12-2024.02 吉林大学 食品科学与工程学院 “鼎新学者”博士后
3.主持科研项目（课题）情况
[1] 国家自然科学基金，青年科学基金项目，30万元，2025.01-2027.12，在研，主持。
[2] 中国博士后科学基金，面上资助，8万元，结题，主持。
[3] 吉林省科技厅，青年成长科技项目，15万元，2023.01-2024.12，在研，主持。
[4] 吉林省科技厅，吉林省自然科学基金，12万元，2024.01-2026.12，在研，主持。
[5] 吉林大学，博士研究生交叉学科科研资助计划，1万元，结题，主持。
4.代表性学术论文
[1] Yuan Liang, Qiuyan Jiang, Yiyao Gong, Yifan Yu, Haoyang Zou, Jingqi Zhao, Tiehua Zhang, Jie Zhang*. In vitro and in silico assessment of endocrine disrupting effects of food contaminants through pregnane X receptor. Food and Chemical Toxicology, 2023, 175: 113711.
[2] Yuan Liang, Yiyao Gong, Yifan Yu, Qiuyan Jiang, Jingqi Zhao, Haoyang Zou, Jie Zhang*. Fluorescence resonance energy transfer-based analytical methods for determination of food contaminants: A review. Food Control, 2023, 152: 109892.
[3] Yuan Liang, Yiyao Gong, Qiuyan Jiang, Yifan Yu, Jie Zhang*. Environmental endocrine disruptors and pregnane X receptor action: A review. Food and Chemical Toxicology, 2023, 179: 113976.
[4] Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang*, Li Ren*. Withaferin A: a potential selective glucocorticoid receptor modulator with anti-inflammatory effect. Food and Chemical Toxicology, 2023, 179: 113949.
[5] Yuan Liang, Tiehua Zhang, Jie Zhang*. Natural tyrosine kinase inhibitors acting on the epidermal growth factor receptor: Their relevance for cancer therapy. Pharmacological Research, 2020, 161: 105164.
[6] Yuan Liang, Tiehua Zhang, Jingqi Zhao, Chenfei Li, Haoyang Zou, Fangyu Li, Jie Zhang*, Li Ren*. Glucocorticoid receptor-mediated alleviation of inflammation by berberine: in vitro, in silico and in vivo investigations. Food & Function, 2021, 12(23): 11974-11986.
[7] Yuan Liang, Jingqi Zhao, Haoyang Zou, Jie Zhang*, Tiehua Zhang*. In vitro and in silico evaluation of EGFR targeting activities of curcumin and its derivatives. Food & Function, 2021, 12(21): 10667-10675.
[8] Yuan Liang, Tiehua Zhang, Siyuan Jing, Peng Zuo, Tiezhu Li, Yongjun Wang, Shaochen Xing, Jie Zhang*, Zhengyi Wei*. 20(S)-Ginsenoside Rg3 inhibits lung cancer cell proliferation by targeting EGFR-mediated Ras/Raf/MEK/ERK pathway. American Journal of Chinese Medicine, 2021, 49(3): 753-765.
[9] Yuan Liang, Tiehua Zhang, Li Ren, Siyuan Jing, Zhuolin Li, Peng Zuo, Tiezhu Li, Yongjun Wang, Jie Zhang*, Zhengyi Wei*. Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway. Environmental Toxicology and Pharmacology, 2021, 81: 103542.
[10] Yuan Liang, Tiehua Zhang, Yantong Sun, Mengxue Diao, Jie Zhang*, Li Ren*. Multi-spectroscopic and molecular modeling studies on the interactions of serum albumin with 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol that inhibit HCT-116 cells proliferation. Food Bioscience, 2021, 40: 100913.
[11] Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li*, Chengyu Lv*. Comparison of the glucocorticoid receptor binding and agonist activities of typical glucocorticoids: Insights into their endocrine disrupting effects. Chemistry & Biodiversity, 2024, 21, e202301525.
[12] Yitong Lu, Sitong Feng, Yueying Zhao, Yingyi Wang, Mengxue Diao, Yuan Liang*, Tiehua Zhang*. Comparison of interactions between alpha-lactalbumin and three protopanaxadiol ginsenosides: Impacts on the structure and antitumor properties. Food Chemistry, 2024, 439: 138046.
[13] Qiuyan Jiang, Tiehua Zhang, Yuan Liang*, Jie Zhang*. Baicalein ameliorates lipid accumulation in HepG2 cells via the pregnane X receptor signaling pathway. Food Bioscience, 2024, 60: 104482.
5.学术奖励情况
2024年 欧倍尔杯第六届全国食品专业工程实践训练综合能力竞赛北部赛区（区赛）特等奖
2024年 吉林省优秀博士学位论文
2021年 博士研究生国家奖学金
